For over 30-years autologous stem cell transplantation has been the standard of care for patients with relapsed diffuse-large B-cell lymphoma (DLBCL). The international Zuma-7 trial randomised 359 patients with relapsed/refractory DLBCL or patients with DLBCL who had relapsed within 12-months of their initial therapy to a novel T-cell immunotherapy called CAR-T (chimeric receptor antigen -T-cell … Read more

For decades the standard treatment for patients with advanced Hodgkin lymphoma has been combination chemotherapy with either ABVD or escalated BEACOPP. Approximately 5 years ago a randomised trial showed that brentuximab vedotin (an antibody conjugate) combined with AVD compared with ABVD improved overall survival in adults with Hodgkin lymphoma. The results of the recent SWOG … Read more

Whilst access to CAR-T therapy is only available by entry into clinical trials in the UK currently, recent results of ciltacabtagene autoleucel (also known as cilta-cel and Carvykit) has been shown to be “remarkably effective” in the treatment of myeloma. The results presented at the ASCO meeting and published in the New England Journal of … Read more