Dr Prem Mahendra MD, FRCP, FRCPath
Consultant Haemato-Oncologist
Haematology News
For older non-transplant eligible patients’ initial treatment options are VR-CAP (bortezomib, rituximab, cyclophosphamide, adriamycin and prednisolone based on the LYM 3002 phase 3 trial of VR-CAP vs R-CHOP which showed a longer survival for patients treated with VR-CAP; or bendamustine and rituximab followed by rituximab maintenance. The TRIANGLE study has demonstrated the benefit of adding … Read more
For over 30-years autologous stem cell transplantation has been the standard of care for patients with relapsed diffuse-large B-cell lymphoma (DLBCL). The international Zuma-7 trial randomised 359 patients with relapsed/refractory DLBCL or patients with DLBCL who had relapsed within 12-months of their initial therapy to a novel T-cell immunotherapy called CAR-T (chimeric receptor antigen -T-cell … Read more
For decades the standard treatment for patients with advanced Hodgkin lymphoma has been combination chemotherapy with either ABVD or escalated BEACOPP. Approximately 5 years ago a randomised trial showed that brentuximab vedotin (an antibody conjugate) combined with AVD compared with ABVD improved overall survival in adults with Hodgkin lymphoma. The results of the recent SWOG … Read more
Whilst access to CAR-T therapy is only available by entry into clinical trials in the UK currently, recent results of ciltacabtagene autoleucel (also known as cilta-cel and Carvykit) has been shown to be “remarkably effective” in the treatment of myeloma. The results presented at the ASCO meeting and published in the New England Journal of … Read more